Escherichia coli is a harmless gut micro-organism, but some pathogenic strains can cause life-threatening infections and other illnesses like urinary tract infections.
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To better understand the risks of antimicrobial resistance due to antimicrobial use in agriculture, aquaculture and livestock, we undertake studies on the biology, ecology and epidemiology of infections. We use the latest technologies, such as whole genome sequencing, to characterise movement of antimicrobial resistance genes within these ecologies and investigate drivers of the emergence and transmission of antimicrobial resistance at the human-animal-environmental interface. In addition, we conduct research on antimicrobial resistance occurrence and residues in food items.
- Generate evidence on the extent of antimicrobial-resistant bacteria and antimicrobial residues in livestock, fish, humans, the environment, water and food
- Understand the transmission and genetic mechanisms of resistance in agriculture and the implications for human and animal health; and
- Develop a range of mathematical and biological models of antimicrobial resistance in low- and middle-income countries to understand the relative contribution of agriculturally-associated antimicrobial resistance to the human burden of antimicrobial resistance and risk of drug-resistant infections in different contexts.