A one-health framework is needed to evaluate the socio-economic impacts of interventions addressing the growing problem of antimicrobial resistance

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Outputs of research on antimicrobial use and AMR transmission dynamics provide the basis to design and test interventions and incentives that lead to behavioural change resulting in reduced antimicrobial use in livestock and aquaculture and reduced public health risks from agriculture-associated AMR. To test how drivers of antimicrobial use can be mitigated, intervention studies will be conducted in hotspot sites. A One Health evaluation framework allows ex-ante and ex-post evaluation of these interventions.


Our main activities are:

  • Develop and evaluate the impact of a range of site-specific interventions in agri- and aquaculture systems, including water and food, to reduce AMR risks to human populations, taking a transdisciplinary approach which engages researchers and stakeholders from different sectors;
  • Develop a decision support tool to help researchers and development agents to identify best-bet interventions in specific settings, based on a novel intervention “typology” framework;
  • Develop and test gender-sensitive pest and pathogen controls to better manage livestock and fish diseases and reduce the use of antimicrobials;
  • Explore feasibility of incentive-based systems, especially in intensifying production systems;
  • Understand costs and benefits of interventions to tackle AMR from a One Health perspective, at different levels of analysis (stakeholder, value chain, ecosystem and national);
  • Characterise gender-differential impacts of interventions on poor farmers, vulnerable groups and address other societal objectives such as attaining nutrition security; and 
  • Understand the potential of market demand/pull for responsibly-produced foods (animal source foods, fish, and crops).


The case studies featured below illustrate ongoing and past research and provide insights into how AMR research is done within the CGIAR AMR hub.